Differentiate or Die: 3-Bromopyruvate and Pluripotency in Mouse Embryonic Stem Cells
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چکیده
منابع مشابه
Differentiate or Die: 3-Bromopyruvate and Pluripotency in Mouse Embryonic Stem Cells
BACKGROUND Pluripotent embryonic stem cells grown under standard conditions (ESC) have a markedly glycolytic profile, which is shared with many different types of cancer cells. Thus, some therapeutic strategies suggest that pharmacologically shifting cancer cells towards an oxidative phenotype, using glycolysis inhibitors, may reduce cancer aggressiveness. Given the metabolic parallels between ...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0135617